• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development.基于N-钙黏蛋白的黏附连接在发育过程中调节神经祖细胞的维持、增殖和分化。
Cell Adh Migr. 2015;9(3):183-92. doi: 10.1080/19336918.2015.1005466. Epub 2015 Apr 14.
2
N-cadherin regulates the proliferation and differentiation of ventral midbrain dopaminergic progenitors.N-钙黏蛋白调节腹侧中脑神经前体细胞的增殖和分化。
Dev Neurobiol. 2013 Jul;73(7):518-29. doi: 10.1002/dneu.22077. Epub 2013 May 14.
3
The role of adherens junctions in the developing neocortex.黏着连接在新皮质发育中的作用。
Cell Adh Migr. 2015;9(3):167-74. doi: 10.1080/19336918.2015.1027478.
4
Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity.Dbnl 和 β-连环蛋白促进前 N-钙黏蛋白的加工，以维持顶底极性。
J Cell Biol. 2021 Jun 7;220(6). doi: 10.1083/jcb.202007055. Epub 2021 May 3.
5
N-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube.N-钙黏蛋白介导的细胞黏附限制了背侧神经管中的细胞增殖。
Mol Biol Cell. 2011 May;22(9):1505-15. doi: 10.1091/mbc.E10-08-0675. Epub 2011 Mar 9.
6
Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-beta-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: an in vivo study using an androgen suppression model.通过N-钙黏蛋白-β-连环蛋白蛋白复合物的蛋白质-蛋白质相互作用变化调节支持细胞-生殖细胞黏附连接动力学，这种变化可能由c-Src和与肌管蛋白相关的蛋白2介导：一项使用雄激素抑制模型的体内研究
Endocrinology. 2005 Mar;146(3):1268-84. doi: 10.1210/en.2004-1194. Epub 2004 Dec 9.
7
Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells.Wnt/β-连环蛋白信号通路调控小鼠皮质前体细胞的连续命运决定。
Stem Cells. 2015 Jan;33(1):170-82. doi: 10.1002/stem.1820.
8
Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.黏附连接蛋白在顶端足突的黏附对于脊椎动物中 Notch 信号的活性控制神经发生是必需的。
Development. 2014 Apr;141(8):1671-82. doi: 10.1242/dev.102988.
9
Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis.IQGAP1、Cdc42与钙黏蛋白/连环蛋白复合物之间的相互作用调节睾丸中支持细胞-生殖细胞黏附连接的动态变化。
J Cell Physiol. 2005 Jan;202(1):49-66. doi: 10.1002/jcp.20098.
10
Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study.睾丸中Fer激酶/FerT与黏着连接动力学：一项体内外研究
Biol Reprod. 2003 Aug;69(2):656-72. doi: 10.1095/biolreprod.103.016881. Epub 2003 Apr 16.

引用本文的文献

1
Valproic Acid Reduces Invasiveness and Cellular Growth in 2D and 3D Glioblastoma Cell Lines.丙戊酸可降低二维和三维胶质母细胞瘤细胞系的侵袭性及细胞生长。
Int J Mol Sci. 2025 Jul 9;26(14):6600. doi: 10.3390/ijms26146600.
2
APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids.APOE4影响人类大脑类器官中的皮质神经发育并改变网络形成。
Stem Cell Reports. 2025 Jul 8;20(7):102537. doi: 10.1016/j.stemcr.2025.102537. Epub 2025 Jun 19.
3
Engineering Cellular Self-Adhesions Inside 3D Printed Micro-Arches to Enhance Cell:Biomaterial Attachment.在3D打印微拱内构建细胞自粘附结构以增强细胞与生物材料的附着
Adv Mater. 2025 Aug;37(32):e2502425. doi: 10.1002/adma.202502425. Epub 2025 May 24.
4
Spheroid morphology of lung cancer cell lines correlates with oncological profiles.肺癌细胞系的球体形态与肿瘤学特征相关。
Discov Oncol. 2025 Apr 28;16(1):627. doi: 10.1007/s12672-025-02132-y.
5
Effects of Phytocompounds on Proliferation and the Epithelial-Mesenchymal Transition Process in T98G Glioblastoma Cells.植物化合物对T98G胶质母细胞瘤细胞增殖及上皮-间质转化过程的影响
Mar Drugs. 2025 Apr 16;23(4):173. doi: 10.3390/md23040173.
6
A cost- and time-efficient method for high-throughput cryoprocessing and tissue analysis using multiplexed tissue molds.一种使用多重组织模具进行高通量冷冻处理和组织分析的经济高效且省时的方法。
Cell Rep Methods. 2025 Apr 21;5(4):101023. doi: 10.1016/j.crmeth.2025.101023.
7
N-cadherin facilitates trigeminal sensory neuron outgrowth and target tissue innervation.N-钙黏蛋白促进三叉神经感觉神经元的生长和靶组织的神经支配。
Development. 2025 May 1;152(9). doi: 10.1242/dev.204369.
8
Effects of Complex I Inhibition on the Architecture of Neural Rosettes Differentiated from Human-Induced Pluripotent Stem Cells.复合体I抑制对源自人诱导多能干细胞的神经玫瑰花结结构的影响。
Stem Cells Dev. 2025 Apr;34(7-8):164-176. doi: 10.1089/scd.2024.0169. Epub 2025 Mar 12.
9
Effects of macrophages on the osteogenic differentiation of adipose tissue-derived stem cells in two-dimensional and three-dimensional cocultures.巨噬细胞对二维和三维共培养体系中脂肪组织来源干细胞成骨分化的影响。
World J Stem Cells. 2025 Feb 26;17(2):99326. doi: 10.4252/wjsc.v17.i2.99326.
10
Templated Pluripotent Stem Cell Differentiation via Substratum-Guided Artificial Signaling.通过基底导向的人工信号进行模板化多能干细胞分化。
ACS Biomater Sci Eng. 2024 Oct 14;10(10):6465-6482. doi: 10.1021/acsbiomaterials.4c00885. Epub 2024 Oct 1.

本文引用的文献

1
Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells.Wnt/β-连环蛋白信号通路调控小鼠皮质前体细胞的连续命运决定。
Stem Cells. 2015 Jan;33(1):170-82. doi: 10.1002/stem.1820.
2
Force-dependent conformational switch of α-catenin controls vinculin binding.力依赖性α-连环蛋白构象开关控制着与纽蛋白的结合。
Nat Commun. 2014 Jul 31;5:4525. doi: 10.1038/ncomms5525.
3
N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions.N-钙黏蛋白促进 SVZ 神经干细胞龛中的神经祖细胞募集和迁移进入脱髓鞘病变。
J Neurosci. 2014 Jul 16;34(29):9590-606. doi: 10.1523/JNEUROSCI.3699-13.2014.
4
The transcription factor Fezf2 directs the differentiation of neural stem cells in the subventricular zone toward a cortical phenotype.转录因子 Fezf2 指导侧脑室下区神经干细胞向皮质表型分化。
Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10726-31. doi: 10.1073/pnas.1320290111. Epub 2014 Jul 7.
5
MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.MT5-MMP 通过切割 N-钙黏蛋白调节成体神经干细胞的功能静止。
Nat Cell Biol. 2014 Jul;16(7):629-38. doi: 10.1038/ncb2993. Epub 2014 Jun 22.
6
Involvement of N-cadherin/β-catenin interaction in the micro/nanotopography induced indirect mechanotransduction.N-钙黏蛋白/β-连环蛋白相互作用在微纳形貌诱导的间接机械转导中的作用。
Biomaterials. 2014 Aug;35(24):6206-18. doi: 10.1016/j.biomaterials.2014.04.068. Epub 2014 May 10.
7
Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.黏附连接蛋白在顶端足突的黏附对于脊椎动物中 Notch 信号的活性控制神经发生是必需的。
Development. 2014 Apr;141(8):1671-82. doi: 10.1242/dev.102988.
8
Neurogenesis during development of the vertebrate central nervous system.脊椎动物中枢神经系统发育过程中的神经发生。
EMBO Rep. 2014 Apr;15(4):351-64. doi: 10.1002/embr.201438447. Epub 2014 Mar 17.
9
miR379-410 cluster miRNAs regulate neurogenesis and neuronal migration by fine-tuning N-cadherin.miR379-410 簇 miRNA 通过精细调节 N-钙黏蛋白来调控神经发生和神经元迁移。
EMBO J. 2014 Apr 16;33(8):906-20. doi: 10.1002/embj.201386591. Epub 2014 Mar 10.
10
Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features.β-连环蛋白显性突变导致伴有明显综合征特征的智力障碍。
J Clin Invest. 2014 Apr;124(4):1468-82. doi: 10.1172/JCI70372. Epub 2014 Mar 10.

基于N-钙黏蛋白的黏附连接在发育过程中调节神经祖细胞的维持、增殖和分化。

N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development.

作者信息

Miyamoto Yasunori, Sakane Fumi, Hashimoto Kei

机构信息

a The Graduate School of Humanities and Sciences; Ochanomizu University ; Tokyo , Japan.

出版信息

Cell Adh Migr. 2015;9(3):183-92. doi: 10.1080/19336918.2015.1005466. Epub 2015 Apr 14.

DOI:10.1080/19336918.2015.1005466
PMID:25869655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4594476/
Abstract

This review addresses our current understanding of the regulatory mechanism by which N-cadherin, a classical cadherin, affects neural progenitor cells (NPCs) during development. N-cadherin is responsible for the integrity of adherens junctions (AJs), which develop in the sub-apical region of NPCs in the neural tube and brain cortex. The apical domain, which contains the sub-apical region, is involved in the switching from symmetric proliferative division to asymmetric neurogenic division of NPCs. In addition, N-cadherin-based AJ is deeply involved in the apico-basal polarity of NPCs and the regulation of Wnt-β-catenin, hedgehog (Hh), and Notch signaling. In this review, we discuss the roles of N-cadherin in the maintenance, proliferation, and differentiation of NPCs through components of AJ, β-catenin and αE-catenin.

摘要

本综述阐述了我们目前对经典钙黏蛋白N-钙黏蛋白在发育过程中影响神经祖细胞（NPCs）的调控机制的理解。N-钙黏蛋白负责黏附连接（AJs）的完整性，黏附连接在神经管和大脑皮层的NPCs的顶端下区域形成。包含顶端下区域的顶端结构域参与了NPCs从对称增殖分裂向不对称神经源性分裂的转变。此外，基于N-钙黏蛋白的AJs深度参与了NPCs的顶-基极性以及Wnt-β-连环蛋白、刺猬信号通路（Hh）和Notch信号通路的调控。在本综述中，我们通过AJs的组成成分β-连环蛋白和αE-连环蛋白来探讨N-钙黏蛋白在NPCs的维持、增殖和分化中的作用。