基于N-钙黏蛋白的黏附连接在发育过程中调节神经祖细胞的维持、增殖和分化。
N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development.
作者信息
Miyamoto Yasunori, Sakane Fumi, Hashimoto Kei
机构信息
a The Graduate School of Humanities and Sciences; Ochanomizu University ; Tokyo , Japan.
出版信息
Cell Adh Migr. 2015;9(3):183-92. doi: 10.1080/19336918.2015.1005466. Epub 2015 Apr 14.
Abstract
This review addresses our current understanding of the regulatory mechanism by which N-cadherin, a classical cadherin, affects neural progenitor cells (NPCs) during development. N-cadherin is responsible for the integrity of adherens junctions (AJs), which develop in the sub-apical region of NPCs in the neural tube and brain cortex. The apical domain, which contains the sub-apical region, is involved in the switching from symmetric proliferative division to asymmetric neurogenic division of NPCs. In addition, N-cadherin-based AJ is deeply involved in the apico-basal polarity of NPCs and the regulation of Wnt-β-catenin, hedgehog (Hh), and Notch signaling. In this review, we discuss the roles of N-cadherin in the maintenance, proliferation, and differentiation of NPCs through components of AJ, β-catenin and αE-catenin.
摘要
本综述阐述了我们目前对经典钙黏蛋白N-钙黏蛋白在发育过程中影响神经祖细胞（NPCs）的调控机制的理解。N-钙黏蛋白负责黏附连接（AJs）的完整性，黏附连接在神经管和大脑皮层的NPCs的顶端下区域形成。包含顶端下区域的顶端结构域参与了NPCs从对称增殖分裂向不对称神经源性分裂的转变。此外，基于N-钙黏蛋白的AJs深度参与了NPCs的顶-基极性以及Wnt-β-连环蛋白、刺猬信号通路（Hh）和Notch信号通路的调控。在本综述中，我们通过AJs的组成成分β-连环蛋白和αE-连环蛋白来探讨N-钙黏蛋白在NPCs的维持、增殖和分化中的作用。
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