涉及顺式-β-内酰胺可控双极性重排的 xanthanolides 的对映选择性和集体合成。
Enantioselective and collective syntheses of xanthanolides involving a controllable dyotropic rearrangement of cis-β-lactones.
机构信息
The Comprehensive AIDS Research Center, Department of Pharmacology & Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China.
出版信息
Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6984-8. doi: 10.1002/anie.201202643. Epub 2012 Jun 4.
PMID:22674838
Abstract
Let's swap: a scalable, atom-economic, enantio-, and diastereoselective synthetic route to trisubstituted γ-butyrolactones based on a Wagner-Meerwein-type dyotropic rearrangement of cis-β-lactones is described. This methodology was applied in efficient and protecting-group-free formal syntheses and total syntheses of various xanthanolide natural products.
摘要
让我们进行交换
一种基于顺式-β-内酰胺 Wagner-Meerwein 型重排的、可伸缩、原子经济性、对映选择性和非对映选择性的合成三取代γ-丁内酯的方法。该方法已应用于各种 xanthanolide 天然产物的高效、无保护基的形式合成和全合成中。
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