Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany.
Angew Chem Int Ed Engl. 2012 Jul 9;51(28):7028-30. doi: 10.1002/anie.201202795. Epub 2012 Jun 6.
Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.
连续合成与连续纯化相结合，可从粗反应混合物中生产出纯产品。在 2,4-二氟硝基苯与吗啉的亲核芳香取代反应中，通过将流动反应器与模拟移动床（SMB）色谱模块相耦合，可以将所需的单取代产物连续地从副产物中以超过 99%的纯度分离出来。
