Bae Youn-Sang, Lee Chang-Ha
Department of Chemical Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, South Korea.
J Chromatogr A. 2006 Jul 28;1122(1-2):161-73. doi: 10.1016/j.chroma.2006.04.040. Epub 2006 May 11.
A new "partial-discard" operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. This strategy was applied to the four-zone SMB process with two columns per zone for binary separation within the linear range. The "partial-discard" strategy significantly enhanced the purity or enrichment when the discard time and discard length were controlled. In addition, the "partial-feed with partial-discard" strategy improved remarkably the extract and raffinate purities at an intermediate feed time compared with the "partial-feed" operation. Adjustments of the discard length and discard time played key roles in achieving the desired product purity in SMB chromatographic performance.
一种新的“部分舍弃”操作策略被开发出来，以提高模拟移动床（SMB）色谱法所能达到的性能，尤其是纯度。该策略应用于每个区域有两根色谱柱的四区SMB过程，用于在线性范围内进行二元分离。当舍弃时间和舍弃长度得到控制时，“部分舍弃”策略显著提高了纯度或富集度。此外，与“部分进料”操作相比，“部分进料与部分舍弃”策略在中间进料时间显著提高了萃余液和萃取液的纯度。舍弃长度和舍弃时间的调整在实现SMB色谱性能中所需的产品纯度方面起着关键作用。
