Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Curr Opin Immunol. 2012 Aug;24(4):398-404. doi: 10.1016/j.coi.2012.04.010. Epub 2012 Jun 5.
The Nod-like receptor (NLR) family of intracellular pattern recognition molecules plays critical roles in the control of inflammation through the modulation of different signalling pathways, including those dependent on NF-κB and caspase-1-mediated cleavage of interleukin (IL)-1β and IL-18. A number of NLRs or NLR-associated proteins have been genetically associated with susceptibility to inflammatory bowel disease (IBD), either Crohn's disease or ulcerative colitis. Accordingly, recent studies have examined the role of NLR proteins in chemical-induced or bacteria-induced murine models of colitis. In this review, we will discuss the genetic associations of NLRs with IBD and the research using NLR-deficient mice in different colitis models.
Nod 样受体（NLR）家族是细胞内模式识别分子，通过调节不同的信号通路，包括依赖 NF-κB 和半胱天冬酶-1 介导的白细胞介素（IL）-1β和 IL-18 切割的信号通路，在炎症控制中发挥关键作用。许多 NLR 或与 NLR 相关的蛋白质已在遗传上与炎症性肠病（IBD），无论是克罗恩病还是溃疡性结肠炎易感性相关。因此，最近的研究检查了 NLR 蛋白在化学诱导或细菌诱导的结肠炎小鼠模型中的作用。在这篇综述中，我们将讨论 NLR 与 IBD 的遗传关联以及在不同结肠炎模型中使用 NLR 缺陷小鼠的研究。
