Petrov N A, Vasilenko S K, Gorbunov Iu A, Vtorushina I A, Grinbaum E B, Litvinova O M, Luzianina T Ia, Golubev D B
Vopr Virusol. 1990 Sep-Oct;35(5):372-3.
The hemagglutinin gene primary structure of influenza virus A/Riga/9977/86 (H3N2) belonging to the "Coen/84" antigenic subgroup was determined by primer sequencing. A comparative analysis confirmed that the reversions of amino acids in the late stages of the H3 influenza virus subtype antigenic drift became more frequent and the antigenic variants remained in epidemic circulation longer. The possible role of some mutations is discussed.
通过引物测序确定了属于“Coen/84”抗原亚组的甲型流感病毒A/里加/9977/86(H3N2)的血凝素基因一级结构。比较分析证实,H3流感病毒亚型抗原漂移后期氨基酸的回复变得更加频繁,抗原变体在流行传播中持续的时间更长。文中讨论了一些突变可能发挥的作用。