Bikour M H, Frost E H, Deslandes S, Talbot B, Weber J M, Elazhary Y
Section de virologie, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.
J Gen Virol. 1995 Mar;76 ( Pt 3):697-703. doi: 10.1099/0022-1317-76-3-697.
Of the four pandemic strains of human influenza A virus observed this century, the 1977 virus strain was very similar in all genes to a 1950 isolate. Since mammalian influenza A viruses change annually by genetic drift, this reappearance could only be attributed at that time to conservation of the virus in a frozen state. We report here the isolation of swine influenza A viruses with haemagglutinin and nucleoprotein genes which are virtually identical to those of the human virus that circulated in 1975. We have also found serological evidence that this virus is circulating extensively in Quebec swine herds. We propose that human-like H3N2 influenza A strains may remain invariant for long periods in swine, which may serve as a reservoir for human pandemics.
在本世纪观察到的四种甲型人流感病毒大流行毒株中，1977年的病毒株在所有基因上都与1950年分离出的毒株非常相似。由于甲型流感病毒在哺乳动物中每年都会通过基因漂移发生变化，这种再次出现当时只能归因于病毒以冷冻状态保存下来。我们在此报告分离出甲型猪流感病毒，其血凝素和核蛋白基因与1975年流行的人类病毒的基因几乎完全相同。我们还发现血清学证据表明这种病毒在魁北克猪群中广泛传播。我们提出，类似人类的H3N2甲型流感毒株可能在猪中长期保持不变，猪可能成为人类大流行病毒的储存库。
