Department of Maternal and Reproductive Health, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Fetal Diagn Ther. 2012;32(4):292-4. doi: 10.1159/000337612. Epub 2012 Jun 1.
Maternal hepatitis infection, excepting hepatitis E, causing isolated fetal ascites with variable outcome has been reported previously. We present a case of maternal hepatitis E virus (HEV) infection causing isolated fetal ascites which resolved spontaneously during pregnancy and resulted in a term live-born baby with anti-HEV seropositivity. A 39-year-old primigravida woman was diagnosed with acute HEV infection at 15 weeks of gestation. Ultrasound at 19 weeks showed significant fetal ascites with abdominal calcifications. Fetal karyotype did not show any abnormality. Cord blood was positive for anti-HEV IgM and negative for other intrauterine infections. Ultrasound at 25 weeks showed partial resolution of fetal ascites with complete resolution at 30 weeks. She delivered a healthy baby at 38 completed weeks, with normal liver enzymes at birth and 1-month follow-up.
先前已有报道称，除戊型肝炎外，母体肝炎感染可导致孤立性胎儿腹水，其结局不一。我们报告了 1 例母体戊型肝炎病毒（HEV）感染导致孤立性胎儿腹水的病例，该病例在妊娠期间自发消退，足月分娩出抗-HEV 血清阳性的活婴。1 名 39 岁初产妇于妊娠 15 周时被诊断为急性 HEV 感染。19 周时的超声检查显示胎儿腹水明显，伴腹部钙化。胎儿染色体核型未见异常。脐血抗-HEV IgM 阳性，其他宫内感染阴性。25 周时的超声检查显示胎儿腹水部分消退，30 周时完全消退。她于 38 周时足月分娩，出生时肝功能正常，1 个月后随访仍正常。
