Department of Mechanical and Aerospace Engineering, Institute for Biomedical Engineering and Institute for Nanotechnology, The George Washington University, 726 Phillips Hall, 801 22nd Street NW, Washington, DC 20052, USA.
Ann Biomed Eng. 2012 Aug;40(8):1628-40. doi: 10.1007/s10439-012-0605-5. Epub 2012 Jun 8.
This review provides a brief synopsis of the anatomy and physiology of the osteochondral interface, scaffold-based and non-scaffold based approaches for engineering both tissues independently as well as recent developments in the manufacture of gradient constructs. Novel manufacturing techniques and nanotechnology will be discussed with potential application in osteochondral interfacial tissue engineering.
这篇综述简要概述了骨软骨界面的解剖结构和生理学,以及用于独立工程化这两种组织的基于支架和非支架的方法,以及梯度构建体制造的最新进展。本文还将讨论新型制造技术和纳米技术在骨软骨界面组织工程中的潜在应用。