Oprita Elena Iulia, Iosageanu Andreea, Craciunescu Oana
National Institute of R&D for Biological Sciences, 296, Splaiul Independentei, 060031 Bucharest, Romania.
Gels. 2022 Oct 12;8(10):648. doi: 10.3390/gels8100648.
Osteochondral structure reconstruction by tissue engineering, a challenge in regenerative medicine, requires a scaffold that ensures both articular cartilage and subchondral bone remodeling. Functional hydrogels and scaffolds present a strategy for the controlled delivery of signaling molecules (growth factors and therapeutic drugs) and are considered a promising therapeutic approach. Icariin is a pharmacologically-active small molecule of prenylated flavonol glycoside and the main bioactive flavonoid isolated from spp. The in vitro and in vivo testing of icariin showed chondrogenic and ostseoinductive effects, comparable to bone morphogenetic proteins, and suggested its use as an alternative to growth factors, representing a low-cost, promising approach for osteochondral regeneration. This paper reviews the complex structure of the osteochondral tissue, underlining the main aspects of osteochondral defects and those specifically occurring in osteoarthritis. The significance of icariin's structure and the extraction methods were emphasized. Studies revealing the valuable chondrogenic and osteogenic effects of icariin for osteochondral restoration were also reviewed. The review highlighted th recent state-of-the-art related to hydrogels and scaffolds enriched with icariin developed as biocompatible materials for osteochondral regeneration strategies.
通过组织工程进行骨软骨结构重建是再生医学中的一项挑战，需要一种能够确保关节软骨和软骨下骨重塑的支架。功能性水凝胶和支架为信号分子（生长因子和治疗药物）的可控递送提供了一种策略，被认为是一种有前景的治疗方法。淫羊藿苷是一种具有药理活性的异戊烯基黄酮醇苷小分子，是从 属植物中分离出的主要生物活性黄酮类化合物。淫羊藿苷的体外和体内试验显示出与骨形态发生蛋白相当的软骨生成和成骨诱导作用，并表明其可用作生长因子的替代品，是一种低成本、有前景的骨软骨再生方法。本文综述了骨软骨组织的复杂结构，强调了骨软骨缺损以及骨关节炎中特有的主要方面。强调了淫羊藿苷结构和提取方法的重要性。还综述了揭示淫羊藿苷对骨软骨修复具有宝贵软骨生成和成骨作用的研究。该综述突出了与富含淫羊藿苷的水凝胶和支架相关的最新技术水平，这些水凝胶和支架被开发为用于骨软骨再生策略的生物相容性材料。
