Department of Psychiatry, University of California, 220 Dickinson St., Suite B, San Diego, CA, 92103, USA.
AIDS Behav. 2012 Nov;16(8):2279-85. doi: 10.1007/s10461-012-0229-7.
HIV-seropositive individuals with low cognitive reserve are at high risk for developing HIV-associated neurocognitive disorders (HAND). The present study evaluated the hypothesis that cognitive reserve would also play a unique role in the expression of everyday functioning complications among those with HAND (i.e., syndromic versus subsyndromic impairment). Eighty-six individuals with HIV infection were evaluated; 53 individuals evidenced normal neurocognitive performance, 16 had subsyndromic HAND (i.e., asymptomatic neurocognitive impairment), and 17 were diagnosed with syndromic HAND based on a comprehensive neurobehavioral evaluation. Cognitive reserve represented a combined score including years of education, estimated verbal IQ, and highest occupational attainment. The groups were comparable (e.g. demographics), and the HAND groups had similar rates of global neurocognitive impairment. The syndromic HAND group evidenced lower reserve scores relative to both other groups, suggesting that individuals with lower reserve may be less able to effectively counteract their neurocognitive impairment to maintain independence in daily living activities than HIV-infected individuals with high cognitive reserve.
HIV 血清阳性且认知储备较低的个体发生与 HIV 相关的神经认知障碍（HAND）的风险较高。本研究评估了这样一个假设，即认知储备也将在 HAND 患者（即综合征性与亚综合征性损害）日常功能并发症的表现中发挥独特作用。评估了 86 名 HIV 感染者；53 名个体表现出正常的神经认知功能，16 名个体存在亚综合征性 HAND（即无症状性神经认知障碍），17 名个体根据全面的神经行为评估被诊断为综合征性 HAND。认知储备代表了一个综合评分，包括受教育年限、估计的言语智商和最高职业成就。这些组是可比的（例如，人口统计学），并且 HAND 组具有相似的全球神经认知障碍发生率。与其他两组相比，综合征性 HAND 组的储备评分较低，这表明与认知储备较高的 HIV 感染者相比，储备较低的个体可能更难以有效地抵消其神经认知障碍，从而在日常生活活动中保持独立性。
