Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinaerstrasse 13, 80539 Munich, Germany.
Vet Rec. 2012 Jul 28;171(4):97. doi: 10.1136/vr.100635. Epub 2012 Jun 7.
Shampoo therapy is frequently used on pruritic dogs. However, there are few double-blinded, placebo-controlled studies of this form of therapy. This randomised, double-blinded, placebo-controlled study evaluated the efficacy of a commercial medicated shampoo (DermaTopic; Almapharm) containing chlorhexidine, lactoferrin, piroctone olamine, chitosan and essential fatty acids in 27 dogs with mild to moderate allergic pruritus without secondary skin infections. All dogs received shampoo therapy with either DermaTopic or a shampoo vehicle as placebo twice weekly for four weeks. The extent of pruritus was evaluated before the study and then on a daily basis by the owners using a visual analogue scale. Before beginning the treatment and after four weeks, the skin lesions were evaluated by an experienced clinician with a validated lesion score (Canine Atopic Dermatitis Extent and Severity Index - CADESI). The pruritus was reduced significantly by both DermaTopic and placebo. However, there was no significant difference between both groups. There was no statistically significant difference in the CADESI scores pre- and post-treatment in either group or between the two types of treatment. This study provides further evidence of the benefit of shampoo therapy for pruritic dogs.
香波疗法常用于瘙痒的犬只。然而，这种治疗形式的双盲、安慰剂对照研究很少。本项随机、双盲、安慰剂对照研究评估了一种含有洗必泰、乳铁蛋白、吡罗克酮乙醇胺、壳聚糖和必需脂肪酸的商业药用香波（DermaTopic；Almapharm）在 27 只患有轻度至中度过敏性瘙痒但无继发皮肤感染的犬中的疗效。所有犬每周接受两次香波治疗，DermaTopic 组或香波载体组作为安慰剂，为期四周。在研究前和之后的四周内，犬主每天使用视觉模拟量表评估瘙痒程度。在开始治疗前和四周后，经验丰富的临床医生使用经过验证的病变评分（犬特应性皮炎严重程度指数-CADESI）评估皮肤病变。DermaTopic 和安慰剂均能显著减轻瘙痒。然而，两组之间没有显著差异。两组或两种治疗方式在治疗前后的 CADESI 评分均无统计学差异。本研究进一步证明了香波疗法对瘙痒犬的益处。
