靶向肿瘤干细胞：治愈癌症患者的新疗法。
Targeting cancer stem cells: a new therapy to cure cancer patients.
机构信息
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University Guangzhou 510060, China.
出版信息
Am J Cancer Res. 2012;2(3):340-56. Epub 2012 Apr 28.
Abstract
Cancer stem cells (CSCs) have been defined as cells within tumor that possess the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. They have been identified in blood, breast, brain, colon, melanoma, pancreatic, prostate, ovarian, lung cancers and so on. It is often considered to be associated with chemo-resistance and radio-resistance that lead to the failure of traditional therapies. Most therapies are directed at the fast growing tumor mass but not the slow dividing cancer stem cells. Eradicating cancer stem cells, the root of cancer origin and recurrence, has been thought as a promising approach to improve cancer survival or even to cure cancer patients. Understanding the characteristics of cancer stem cells will help to develop novel therapies to eliminate the initiating cancer stem cell, and the relevant patents on the cancer stem cell and cancer therapy by cancer stem cells will be discussed.
摘要
癌症干细胞（CSC）被定义为肿瘤中具有自我更新能力并能产生构成肿瘤的异质性癌细胞谱系的细胞。它们已经在血液、乳腺、脑、结肠、黑色素瘤、胰腺、前列腺、卵巢、肺癌等中被识别。它通常被认为与化疗耐药性和放疗耐药性有关，导致传统疗法的失败。大多数治疗方法针对的是快速生长的肿瘤团块，而不是缓慢分裂的癌症干细胞。根除癌症干细胞，即癌症起源和复发的根源，被认为是改善癌症生存甚至治愈癌症患者的一种有前途的方法。了解癌症干细胞的特征将有助于开发新的疗法来消除起始癌症干细胞，并且将讨论关于癌症干细胞和癌症治疗的相关专利。
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本文引用的文献
1
CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays.使用组织微阵列，CD90 被鉴定为原发性高级别神经胶质瘤中癌症干细胞的候选标志物。
Mol Cell Proteomics. 2012 Jun;11(6):M111.010744. doi: 10.1074/mcp.M111.010744. Epub 2011 Dec 27.
2
ALDH as a tumor marker for pancreatic cancer.
J Gastrointestin Liver Dis. 2011 Dec;20(4):443-4; author reply 444.
3
Salinomycin can effectively kill ALDH(high) stem-like cells on gastric cancer.黏菌素能有效杀死胃癌中 ALDH（高）的干细胞样细胞。
Biomed Pharmacother. 2011 Oct;65(7):509-15. doi: 10.1016/j.biopha.2011.06.006. Epub 2011 Aug 27.
4
Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells.裂环烯醚萜内酯抑制干细胞样 ALDH 阳性前列腺癌细胞。
PLoS One. 2011;6(7):e22118. doi: 10.1371/journal.pone.0022118. Epub 2011 Jul 11.
5
Targeting of pancreatic and prostate cancer stem cell characteristics by Crambe crambe marine sponge extract.海洋海绵提取物岩大戟靶向调控胰腺和前列腺癌干细胞特性。
Int J Cancer. 2012 Apr 1;130(7):1671-81. doi: 10.1002/ijc.26168. Epub 2011 Jul 21.
6
Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells.人类卵巢肿瘤起始细胞的表型异质性和不稳定性。
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6468-73. doi: 10.1073/pnas.1005529108. Epub 2011 Mar 30.
7
Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells.盐霉素对人肺腺癌细胞 A549 中肿瘤干细胞的影响。
Med Chem. 2011 Mar;7(2):106-11. doi: 10.2174/157340611794859307.
8
Role of Notch and its oncogenic signaling crosstalk in breast cancer.Notch及其致癌信号串扰在乳腺癌中的作用。
Biochim Biophys Acta. 2011 Apr;1815(2):197-213. doi: 10.1016/j.bbcan.2010.12.002. Epub 2010 Dec 28.
9
A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer.一种新型 Gemini 维生素 D 类似物抑制乳腺癌干细胞标志物 CD44 的表达。
Mol Pharmacol. 2011 Mar;79(3):360-7. doi: 10.1124/mol.110.068403. Epub 2010 Nov 29.
10
Using ABCG2-molecule-expressing side population cells to identify cancer stem-like cells in a human ovarian cell line.利用 ABCG2 分子表达的侧群细胞鉴定人卵巢癌细胞系中的癌症干细胞样细胞。
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