Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
J Med Entomol. 2012 May;49(3):672-7. doi: 10.1603/me11141.
The objective of this study was to investigate the effects of three fragrance fixatives, Glucam P-20, Vanillin, and Fixolide, on the mosquito repellent property of citronella oil lotions. In the current study, two formulae (A and B) of oil-in-water citronella oil lotions were formulated using different ingredients (emulsifiers [Cremophors or Emulwax], stiffening agents, and emollients). Citronella oil was used at 10% wt:wt. The weight ratios tested between citronella oil and each fixative were 1:0.25, 1:0.5, and 1:1. Overall, 20 formulations, including one with no fixatives for both A and B, were produced, A1-A10 and B1-B10. The repellent activities of these 20 lotions against Aedes aegypti (L.) were tested using a human-bait technique. The types and concentrations of fixatives as well as the compositions of the formulations did affect the protection time of the citronella oil lotions. The lotion containing Emulwax and 5% vanillin (B6) was the most effective repellent. It provided the longest protection time of 4.8 h, which exceeded the minimum requirement of 2 h set by the National Institute of Health, Thailand. The shortest protection time (1 h) was observed in the lotion containing Emulwax and 2.5% Glucam P-20 (B2). It could be concluded that the tested fixatives affected the repellent activity of the citronella oil lotions.
本研究旨在探讨三种香精固定剂（Glucam P-20、香草醛和 Fixolide）对香茅油乳液驱蚊性能的影响。在本研究中，使用不同的成分（乳化剂[Cremophor 或 Emulwax]、增稠剂和润肤剂）配制了两种水包油香茅油乳液配方（A 和 B）。香茅油的用量为 10wt%wt。香茅油与每种固定剂的测试重量比分别为 1:0.25、1:0.5 和 1:1。总的来说，共生产了 20 种配方，其中 A 和 B 都不含固定剂各有 10 种，分别为 A1-A10 和 B1-B10。使用人体诱饵技术测试了这 20 种乳液对埃及伊蚊（Aedes aegypti（L.））的驱蚊活性。固定剂的类型和浓度以及配方的组成确实影响了香茅油乳液的保护时间。含有 Emulwax 和 5%香草醛（B6）的乳液是最有效的驱蚊剂。它提供了最长的 4.8 小时保护时间，超过了泰国国家卫生研究院设定的 2 小时的最低要求。含有 Emulwax 和 2.5%Glucam P-20（B2）的乳液的保护时间最短（1 小时）。可以得出结论，测试的固定剂影响了香茅油乳液的驱蚊活性。
