还原-Heck 方法构建氢薁环系统：恩格勒因的形式合成。
A reductive-Heck approach to the hydroazulene ring system: a formal synthesis of the englerins.
机构信息
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
出版信息
Org Lett. 2012 Jul 6;14(13):3340-3. doi: 10.1021/ol3013167. Epub 2012 Jun 8.
PMID:22679931
Abstract
The reduction of a palladium enolate prior to β-hydride elimination provides a unique reaction for the synthesis of the hydroazulene ring system. When combined with a transannular epoxide rearrangement cascade, the reductive-Heck reaction allows rapid entry to the oxo-bridged guaiane core of the englerins.
摘要
钯烯醇化物的还原反应在β-氢消除之前进行，为合成氢蓝烯环体系提供了独特的反应途径。当与反式环氧化合物重排级联反应结合使用时，还原-Heck 反应可以快速构建到埃格利恩的氧桥冠醚核心。
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