恩格勒菌素：全面综述。
Englerins: A Comprehensive Review.
作者信息
Wu Zhenhua, Zhao Senzhi, Fash David M, Li Zhenwu, Chain William J, Beutler John A
机构信息
Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.
出版信息
J Nat Prod. 2017 Mar 24;80(3):771-781. doi: 10.1021/acs.jnatprod.6b01167. Epub 2017 Feb 7.
Abstract
In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.
摘要
自发现恩格勒菌素A（1）及其在癌症模型中的强大活性以来的十年间，这种天然产物及其类似物一直是众多研究小组进行的大量化学、生物学和临床前研究的主题。本综述总结了已发表的研究结果，并提出了恩格勒菌素类似物进入肾癌及其他病症临床试验所需的进一步研究方向。
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本文引用的文献
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(-)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase.（-）-恩格勒菌素A诱导的细胞毒性由钠离子内流介导，并被钠钾ATP酶抵消。
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Concise, Enantioselective, and Versatile Synthesis of (-)-Englerin A Based on a Platinum-Catalyzed [4C+3C] Cycloaddition of Allenedienes.基于铂催化的[4C+3C]环加成反应，简洁、对映选择性和多功能合成(-)-岩白菜素 A。
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