Wu Zhenhua, Zhao Senzhi, Fash David M, Li Zhenwu, Chain William J, Beutler John A
Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.
J Nat Prod. 2017 Mar 24;80(3):771-781. doi: 10.1021/acs.jnatprod.6b01167. Epub 2017 Feb 7.
In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.
自发现恩格勒菌素A（1）及其在癌症模型中的强大活性以来的十年间，这种天然产物及其类似物一直是众多研究小组进行的大量化学、生物学和临床前研究的主题。本综述总结了已发表的研究结果，并提出了恩格勒菌素类似物进入肾癌及其他病症临床试验所需的进一步研究方向。
