Liu Fudong, Turtzo L Christine, Li Jun, Regard Jean, Worley Paul, Zeevi Neer, McCullough Louise D
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Exp Transl Stroke Med. 2012 Jun 8;4(1):12. doi: 10.1186/2040-7378-4-12.
Vascular Early Response Gene (Verge) is an immediate early gene (IEG) that is up-regulated in endothelial cells in response to a number of stressors, including ischemic stroke. Endothelial cell lines that stably express Verge show enhanced permeability. Increased Verge expression has also been associated with blood brain barrier breakdown. In this study we investigated the role of Verge in ischemic injury induced by middle cerebral artery occlusion (MCAO) in both Verge knockout (KO) and wild type (WT) mice. Verge KO mice had significantly less cerebral edema formation after MCAO compared to WT mice. However, stroke outcome (infarct size and neurological deficit scores) evaluated at either 24 or 72 hours after stroke showed no differences between the two genotypes. Verge deletion leads to decreased edema formation after ischemia; however acute stroke outcomes were unchanged.
血管早期反应基因（Verge）是一种即时早期基因（IEG），在包括缺血性中风在内的多种应激源作用下，内皮细胞中该基因表达上调。稳定表达Verge的内皮细胞系显示出通透性增强。Verge表达增加还与血脑屏障破坏有关。在本研究中，我们在Verge基因敲除（KO）小鼠和野生型（WT）小鼠中研究了Verge在大脑中动脉闭塞（MCAO）诱导的缺血性损伤中的作用。与WT小鼠相比，Verge KO小鼠在MCAO后形成的脑水肿明显更少。然而，在中风后24小时或72小时评估的中风结局（梗死面积和神经功能缺损评分）在两种基因型之间没有差异。Verge缺失导致缺血后水肿形成减少；然而急性中风结局未发生改变。
