Department of Surgery, Faculty of Veterinary Science, The University of Selcuk, Konya, Turkey.
Int Wound J. 2013 Oct;10(5):549-54. doi: 10.1111/j.1742-481X.2012.01021.x. Epub 2012 Jun 11.
In this study, the effects of the wound-covering materials, Acticoat(®) and Cutinova Hydro(®) , on wound healing have been studied in rabbit models with open and tissue-lost wounds with full-thickness flank excisions. Rabbits were used as subjects with three groups of four rabbits each, and trial periods of 7, 14 and 21{\uns}days. Four circular wounds, of 1.5 cm diameter were made two on the right (one of them control) and two on the left (one of them control) of the dorsal sides of the abdomen. Acticoat(®) and Cutinova Hydro(®) were applied on the wounds with suture for a period of 21 days and one each placed on the right and left sides as control with gauze. Biopsy specimens were taken from the animals at the end of the research period to check the length of the epithelium, epithelial thickness, size of wounds, wound granulation tissue formation and histopathological evaluation for clarity. The Acticoat(®) group showed better healing and scar formation compared to the Cutinova Hydro(®) group by macroscopic examination. Epithelial wound length and clarity in terms of statistical difference occurred on day 21 (P <0.05); while the length of the wound epithelium decreased patency, epithelial thickness on days~7, 14 and 21, showed no statistical differences (P >0.05). As a result, the Acticoat(®) wound dressing was determined as a more reliable for the early wound healing. This study has shown the short-term clinical benefits of hydroactive, polyurethane dressings in the management of acute wounds. However, longer periods of wound healing procedure should be planned for reliable and safe results of wound dressing. It has also been concluded that microbiological analyses should be included for more robust and reliable comparisons.
在这项研究中，我们研究了创面覆盖材料 Acticoat(®) 和 Cutinova Hydro(®) 对兔模型中伴有全层腹壁切开的开放性和组织缺失性创面愈合的影响。研究中选用了兔作为实验对象，每组 4 只，共 3 组，实验周期为 7、14 和 21 天。在腹部背部两侧，每只兔子的右侧和左侧各制作 4 个直径为 1.5cm 的圆形创面，其中右侧的 2 个为对照创面（其中 1 个对照创面应用缝线缝合），左侧的 2 个为对照创面（其中 1 个对照创面应用纱布覆盖）。在 21 天的时间里，用缝线将 Acticoat(®) 和 Cutinova Hydro(®) 应用于创面，右侧和左侧各有 1 个创面应用纱布作为对照。在研究结束时，从动物身上取出活检标本，以检查上皮长度、上皮厚度、创面大小、创面肉芽组织形成情况，并进行组织病理学评估。肉眼观察发现，与 Cutinova Hydro(®) 组相比，Acticoat(®) 组的愈合和瘢痕形成更好。在第 21 天，上皮伤口长度和清晰度的差异具有统计学意义（P <0.05）；而在第 7、14 和 21 天，伤口上皮的长度和上皮厚度无统计学差异（P >0.05）。因此，Acticoat(®) 创面敷料被认为在早期创面愈合方面更可靠。这项研究表明，水凝胶活性、聚氨酯敷料在急性创面管理方面具有短期的临床优势。然而，为了获得可靠和安全的创面敷料结果，应计划更长的愈合过程。研究还得出结论，应包括微生物分析，以获得更稳健和可靠的比较结果。
