Kratz Harald, Eberbeck Dietmar, Wagner Susanne, Taupitz Matthias, Schnorr Jörg
Biomed Tech (Berl). 2013 Dec;58(6):509-15. doi: 10.1515/bmt-2012-0057.
Magnetic particle imaging (MPI) is a new imaging technique for visualizing the three-dimensional distribution of superparamagnetic iron oxide nanoparticles with specific properties (MPI tracers). Initial results obtained with MPI using superparamagnetic iron oxide as blood pool markers suggest that the method has great potential for cardiovascular imaging. Conversely, no clinically approved MPI tracers currently exist that could be used to exploit this potential of MPI. This article describes thermal decomposition and coprecipitation, two relevant methods for synthesizing and optimizing superparamagnetic iron oxide nanoparticles for MPI. Furthermore it summarizes the recent literature on MPI tracers and explores what can be learned from structural studies with Resovist(®) for novel synthesis approaches.
磁粒子成像（MPI）是一种用于可视化具有特定性质的超顺磁性氧化铁纳米颗粒（MPI示踪剂）三维分布的新型成像技术。使用超顺磁性氧化铁作为血池标记物通过MPI获得的初步结果表明，该方法在心血管成像方面具有巨大潜力。相反，目前尚无临床批准的可用于发挥MPI这一潜力的MPI示踪剂。本文介绍了热分解法和共沉淀法，这两种用于合成和优化用于MPI的超顺磁性氧化铁纳米颗粒的相关方法。此外，本文总结了近期关于MPI示踪剂的文献，并探讨了从使用Resovist®进行的结构研究中可以获得哪些关于新型合成方法的经验。
