胰岛素样生长因子 1 生理学：来自小鼠模型的启示。
Insulin-like growth factor 1 physiology: lessons from mouse models.
机构信息
Department of Basic Science and Craniofacial Biology, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA.
出版信息
Endocrinol Metab Clin North Am. 2012 Jun;41(2):231-47, v. doi: 10.1016/j.ecl.2012.04.008. Epub 2012 May 15.
Abstract
Insulin-like growth factor 1 (IGF-1) is a pleiotropic polypeptide. Its expression is tightly regulated and it plays significant roles during early development, maturation, and adulthood. This article discusses the roles of IGF-1 in determination of body size, skeletal acquisition, muscle growth, carbohydrate metabolism, and longevity, as learned from mouse models.
摘要
胰岛素样生长因子 1（IGF-1）是一种多效性多肽。其表达受到严格调控，在早期发育、成熟和成年期发挥重要作用。本文从鼠模型中探讨了 IGF-1 在决定体型、骨骼获得、肌肉生长、碳水化合物代谢和长寿中的作用。
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