Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Endocrinol Metab Clin North Am. 2012 Jun;41(2):297-322, vi. doi: 10.1016/j.ecl.2012.04.012. Epub 2012 May 10.
This review describes the current literature on the interaction between insulin-like growth factors, endocrine hormones, and branched-chain amino acids on muscle physiology in healthy young individuals and during select pathologic conditions. Emphasis is placed on the mechanism by which physical and hormonal signals are transduced at the cellular level to either grow or atrophy skeletal muscle. The key role of the mammalian target of rapamycin and its ability to respond to hypertrophic and atrophic signals informs our understanding how a combination of physical, nutritional, and pharmacologic therapies may be used in tandem to prevent or ameliorate reductions in muscle mass.
这篇综述描述了目前关于胰岛素样生长因子、内分泌激素和支链氨基酸在健康年轻个体肌肉生理学以及特定病理情况下相互作用的文献。重点介绍了物理和激素信号在细胞水平上转导的机制，以促进或导致骨骼肌萎缩。雷帕霉素靶蛋白的关键作用及其对肥大和萎缩信号的反应能力，使我们能够更好地理解如何结合物理、营养和药物治疗来预防或改善肌肉减少症。
