Department of Plant and Microbial Biology, 585B Li Ka Shing Center, University of California, Berkeley, CA 94720-3370, USA.
Curr Opin Microbiol. 2012 Aug;15(4):506-11. doi: 10.1016/j.mib.2012.05.010. Epub 2012 Jun 9.
Post-transcriptional, RNA-based regulation is a major contributor to alterations in gene expression, and γ-herpesviruses interface with the host RNA targeting machinery in a variety of ways. Several of these interactions involve coordination with cellular ribonucleases, for example to direct non-canonical processing of viral microRNAs or widespread degradation of cellular messenger RNAs. Conversely, select viral transcripts use both cis-acting and trans-acting mechanisms to evade degradation. The diversity of mechanisms used by these viruses to both engage and escape the cellular RNA decay machinery underscores the influence these pathways exert on cellular and viral gene expression. Further research in this field should help reveal new mechanisms of RNA-based regulation in both infected and uninfected cells.
转录后 RNA 调控是基因表达改变的主要原因之一，γ 疱疹病毒以多种方式与宿主 RNA 靶向机制相互作用。这些相互作用中的几种涉及与细胞核糖核酸酶的协调，例如指导病毒 microRNA 的非规范加工或细胞信使 RNA 的广泛降解。相反，某些病毒转录本使用顺式作用和反式作用机制来逃避降解。这些病毒用来结合和逃避细胞 RNA 降解机制的机制的多样性突出了这些途径对细胞和病毒基因表达的影响。该领域的进一步研究应该有助于揭示受感染和未受感染细胞中基于 RNA 的调控的新机制。
