Laboratoire Antibiotiques Antifongiques, Physico-Chimie, Synthèse et Activité Biologique, Département de Biologie, Faculté des Sciences, Tlemcen University, 13000 Tlemcen, Algeria.
Med Mal Infect. 2012 Jun;42(6):270-5. doi: 10.1016/j.medmal.2012.05.002. Epub 2012 Jun 7.
Naphthoquinone derivatives are under investigation as potential therapeutic agents. The antibacterial and antifungal activity of lawsone and of some novel naphthoquinone derivatives was assessed in vitro.
The antimicrobial activity was determined using diffusion disk and the broth microdilution methods against seven bacteria and three Candida species, according to recommendations of the Clinical and Laboratory Standards Institute.
Two compounds (P05 et P06) presented a good antibacterial effectiveness against two gram-positive bacteria. No antifungal potency was observed against the three Candida albicans strains used in the test.
Our results prove that the introduction of substituents on ketone function position 4 decreased the antimicrobial properties of the synthetized compounds.
萘醌衍生物正被研究作为潜在的治疗药物。本文评估了大黄素和一些新型萘醌衍生物的体外抗菌和抗真菌活性。
根据临床和实验室标准协会的建议，采用扩散盘和肉汤微量稀释法，对七种细菌和三种念珠菌属进行了抗菌活性测定。
两种化合物（P05 和 P06）对两种革兰氏阳性菌表现出良好的抗菌效果。在所测试的三种白色念珠菌菌株中，未观察到抗真菌作用。
我们的结果证明，在酮功能 4 位引入取代基降低了合成化合物的抗菌性能。
