Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.
Eur J Cancer. 2012 Nov;48(16):3009-18. doi: 10.1016/j.ejca.2012.05.011. Epub 2012 Jun 7.
Annually about 500,000 women worldwide are diagnosed with cervical cancer. For many patients, young age at the time of diagnosis and a good prognosis regarding the disease imply a long life with the side-effects and sequels of various treatment options. The present study investigated the extent to which different quality of life (QoL) domains in patients during and after treatment for cervical cancer are affected according to menopausal status, treatment status and treatment modality.
QoL data from 346 cervical cancer patients from 14 countries who were included in a cervical cancer module validation study of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of life Group were analysed according to menopausal status, treatment status and treatment modality. QOL was assessed using the EORTC Quality of life Questionnaire (QLQ)-C30 and the QLQ-CX24 module. Statistical analyses were performed using descriptive statistics and analysis of covariance.
Active treatment had the strongest negative impact on 13 different QoL domains: physical, role, emotional, cognitive, social functioning, global health/QoL, fatigue, nausea and emesis, pain, appetite loss, constipation, symptom experience and sexual enjoyment. Irradiation alone ± other therapy was associated with most symptoms of diarrhoea. Age had the most negative impact on sexual activity and the strongest positive effect on sexual worry.
Our results revealed that patients with cervical carcinoma had different side-effects with different impacts on QOL depending on the menopausal status and therapy modalities. Patients should be informed about the possibility that therapy may have a negative impact on QoL.
全球每年约有 50 万名女性被诊断出患有宫颈癌。对于许多患者来说，诊断时年龄较小且疾病预后良好意味着她们将在长期的生存过程中承受各种治疗方案的副作用和后遗症。本研究旨在调查宫颈癌患者在治疗期间和治疗后，根据绝经状态、治疗状态和治疗方式，不同生活质量（QoL）领域受到的影响程度。
根据绝经状态、治疗状态和治疗方式，对来自 14 个国家的 346 名宫颈癌患者的 QoL 数据进行分析，这些患者均来自欧洲癌症研究与治疗组织（EORTC）生活质量组的宫颈癌模块验证研究。使用 EORTC 生活质量问卷（QLQ）-C30 和 QLQ-CX24 模块评估 QoL。采用描述性统计和协方差分析进行统计分析。
积极治疗对 13 个不同的 QoL 领域产生了最强烈的负面影响：身体、角色、情感、认知、社会功能、总体健康/生活质量、疲劳、恶心和呕吐、疼痛、食欲减退、便秘、症状体验和性享受。单独放疗±其他疗法与大多数腹泻症状有关。年龄对性行为的负面影响最大，对性担忧的影响最强。
我们的研究结果表明，宫颈癌患者根据绝经状态和治疗方式的不同，有不同的副作用，对 QoL 的影响也不同。应告知患者治疗可能对 QoL 产生负面影响的可能性。
