Murgić Jure, Soldić Zeljko, Vrljić Dubravka, Samija Ivan, Kirac Iva, Bolanca Ante, Kusić Zvonko
University of Zagreb, "Sestre milosrdnice" University Hospital Center, Department of Oncology and Nuclear Medicine, Zagreb, Croatia.
Coll Antropol. 2012 Dec;36(4):1335-41.
Quality of life (QoL) is an important outcome in assessment of breast cancer treatment. Data comparing QoL after different adjuvant treatments and QoL data on long-term survivors are modest. The aim of this study was to compare QoL scores of patients receiving adjuvant treatment with long-term breast cancer survivors, and to correlate QoL scores with clinical data. Sixty patients were recruited for the study: 20 during adjuvant radiotherapy, 20 during adjuvant chemotherapy, and 20 long-term breast cancer survivors. QoL was assessed using the self-administered EORTC core questionnaire QLQ-C30 and breast cancer-specific module QLQ-BR23. QoL scores between groups were compared using Kruskal-Wallis test and effects of clinical factors on QoL domains were tested using multiple regression analysis. No differences between three groups were observed in terms of all QoL scores. As measured by QLQ-C30, least affected QoL scales were cognitive functioning, social functioning, and physical functioning in all three patients group, while insomnia and pain scales were the most detrimentally affected. Among the groups, the highest scores of global health status and other functional scales were in adjuvant chemotherapy group. Measured by QLQ-BR23, body image scale was most affected, while sexual functioning scale was minimally affected, in all three groups. Multiple regression analysis has shown that the patient age were the only statistically significant predictor for global health status scale, and constipation scale. Our results demonstrated similar and favorable QoL in all three groups of patients and provided basic information on QoL in Croatian breast cancer patients.
生活质量（QoL）是评估乳腺癌治疗效果的一项重要指标。关于不同辅助治疗后生活质量的比较数据以及长期幸存者的生活质量数据并不多。本研究的目的是比较接受辅助治疗的患者与乳腺癌长期幸存者的生活质量评分，并将生活质量评分与临床数据相关联。该研究招募了60名患者：20名处于辅助放疗阶段，20名处于辅助化疗阶段，20名是乳腺癌长期幸存者。使用患者自行填写的欧洲癌症研究与治疗组织（EORTC）核心问卷QLQ - C30和乳腺癌特异性模块QLQ - BR23评估生活质量。使用Kruskal - Wallis检验比较组间生活质量评分，并使用多元回归分析测试临床因素对生活质量领域的影响。在所有生活质量评分方面，三组之间未观察到差异。通过QLQ - C30测量，在所有三组患者中，受影响最小的生活质量量表是认知功能、社会功能和身体功能，而失眠和疼痛量表受影响最大。在各组中，全球健康状况和其他功能量表的最高分出现在辅助化疗组。通过QLQ - BR23测量，在所有三组中，身体形象量表受影响最大，而性功能量表受影响最小。多元回归分析表明，患者年龄是全球健康状况量表和便秘量表唯一具有统计学意义的预测因素。我们的结果表明，所有三组患者的生活质量相似且良好，并提供了克罗地亚乳腺癌患者生活质量的基本信息。
