Laboratory of Clinical & Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
Curr Opin Virol. 2012 Aug;2(4):426-33. doi: 10.1016/j.coviro.2012.04.007. Epub 2012 Jun 9.
Numerous rotavirus group A (RVA) strains with distinct G-genotype and P-genotype combinations have been described infecting humans worldwide. However, the increasing amount of complete RVA genome data which have become available, suggest that only RVA strains with 2 discrete genotype constellations have been successful in sustaining infection of humans worldwide over longer periods of time. Those genotype constellations have been designated I1-R1-C1-M1-A1-N1-T1-E1-H1 and I2-R2-C2-M2-A2-N2-T2-E2-H2 and are also known as Wa-like and DS-1-like, respectively. RVAs of other genotype constellations which were able to spread to a limited extent in the human population are AU-1-related RVA strains (I3-R3-C3-M3-A3/A12-N3-T3-E3-H3/H6) in combination with G3P[9] or G12P[9], and neonatal G10P[11] RVA strains in India (bovine×human Wa-like reassortants). On the basis of the analysis of complete genomes, it is suggested that the overall genetic diversity of epidemiologically widespread human RVA strains is more limited than generally assumed. This conclusion has consequences for how we look at host range restriction and the criteria according to which the effectiveness of RVA universal mass vaccination programs is assessed.
已描述了许多具有不同 G 基因型和 P 基因型组合的轮状病毒 A（RVA）株在全球范围内感染人类。然而，随着越来越多完整的 RVA 基因组数据的出现，表明只有具有 2 种离散基因型组合的 RVA 株在较长时间内成功地在全球范围内维持了人类的感染。这些基因型组合被指定为 I1-R1-C1-M1-A1-N1-T1-E1-H1 和 I2-R2-C2-M2-A2-N2-T2-E2-H2，分别也称为 Wa 样和 DS-1 样。其他基因型组合的 RVAs 能够在人类中有限程度传播，包括与 G3P[9]或 G12P[9]结合的 AU-1 相关的 RVA 株（I3-R3-C3-M3-A3/A12-N3-T3-E3-H3/H6），以及在印度的新生 G10P[11]RVA 株（牛×人类 Wa 样重组体）。基于完整基因组的分析，提示在流行病学上广泛传播的人类 RVA 株的总体遗传多样性比普遍认为的更为有限。这一结论对我们如何看待宿主范围限制以及根据哪些标准评估 RVA 通用大规模疫苗接种计划的效果产生了影响。
