Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, China.
Epilepsy Behav. 2012 Aug;24(4):435-8. doi: 10.1016/j.yebeh.2012.05.001. Epub 2012 Jun 9.
One hundred and forty-four people with convulsive seizures (CS) and 144 healthy controls were evaluated for cognitive function, using a battery of neuropsychological tests. People with CS performed significantly worse than the controls on the Mini-Mental State Examination, Hamilton Depression Rating Scale, auditory verbal learning test, digit span test, verbal fluency test, and digit cancellation test. The percentage of patients who had abnormal scores on the Hamilton Depression Rating Scale was higher than that of controls (54.9% vs. 7.6%, p<0.001). Cognitive functional impairment was detected in 65.3% of the patients and 29.2% of the controls (p<0.001). People with CS presented with depressive mood and a wide range of cognitive deficits, particularly deficits in episodic declarative memory, attentional capacity, semantic memory, and mental speed. Years in education were positively associated with the cognitive performance of people with CS (OR=0.655, 95% CI: 0.486-0.882, p=0.005).
144 名癫痫发作（CS）患者和 144 名健康对照者接受了一系列神经心理学测试，以评估其认知功能。CS 患者在简易精神状态检查、汉密尔顿抑郁评定量表、听觉词语学习测试、数字跨度测试、词语流畅性测试和数字删除测试中的表现明显差于对照组。汉密尔顿抑郁评定量表异常评分的患者比例高于对照组（54.9%比 7.6%，p<0.001）。认知功能障碍在 65.3%的患者和 29.2%的对照组中被检测到（p<0.001）。CS 患者表现出抑郁情绪和广泛的认知缺陷，特别是在情景性陈述性记忆、注意力容量、语义记忆和心理速度方面存在缺陷。受教育年限与 CS 患者的认知表现呈正相关（OR=0.655，95%CI：0.486-0.882，p=0.005）。
