School of Veterinary and Biomedical Science, Faculty of Health Sciences, Murdoch University, Perth, 6150 WA, Australia.
Res Vet Sci. 2012 Dec;93(3):1426-33. doi: 10.1016/j.rvsc.2012.05.003. Epub 2012 Jun 9.
The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180 min after treatment with propantheline (100mg), hyoscine (120 mg) or saline. Both propantheline and hyoscine reduced GIT sounds, with propantheline having a longer duration of effect (≥120 min). Both drugs elevated HR relative to the control baseline period (P<0.05), with the effects of propantheline again being of longer duration. HRV analysis indicated that propantheline suppressed Total Power (P<0.05), and both the high frequency (HF) and low frequency (LF) components of the power spectral analysis for up to 60-90 min post treatment. Hyoscine had no effect on HRV Total Power but reduced the HF component for 30 min after drug injection. Time domain variables correlated with Total Power and HF data (P<0.01). The marked effect of these compounds on parasympathetic control of cardiac and GIT function in normal horses should be taken into consideration when evaluating a clinical response to these agents.
本研究旨在观察氢溴酸莨菪碱（hyoscine）和溴丙胺太林（propantheline）对正常马匹心率（HR）、心率变异性（HRV）和胃肠道（GIT）收缩的影响。在给予马匹 propantheline（100mg）、hyoscine（120mg）或生理盐水后，对其进行 180min 的心电图（ECG）记录。结果显示，propantheline 和 hyoscine 均降低了 GIT 声音，propantheline 的作用持续时间更长（≥120min）。与对照组相比，两药均升高了 HR（P<0.05），且 propantheline 的作用持续时间更长。HRV 分析表明，propantheline 抑制了总功率（P<0.05），且对功率谱分析的高频（HF）和低频（LF）分量的抑制作用持续了 60-90min。hyoscine 对 HRV 总功率没有影响，但在药物注射后 30min 内降低了 HF 分量。时域变量与总功率和 HF 数据相关（P<0.01）。这些化合物对正常马匹心脏和 GIT 功能的副交感神经控制具有显著影响，在评估这些药物的临床反应时应予以考虑。
