Gehlen Heidrun, Faust Maria-Dorothee, Grzeskowiak Remigiusz M, Trachsel Dagmar S
Equine Clinic, Veterinary Department, Freie University Berlin, 14163 Berlin, Germany.
Large Animal Clinical Science, College of Veterinary Medicine, University of Tennessee, 2407 River Dr, Knoxville, TN 37996, USA.
Animals (Basel). 2020 Sep 2;10(9):1563. doi: 10.3390/ani10091563.
Heart rate variability (HRV) is a noninvasive technique to detect changes in the autonomous nervous system. It has rarely been investigated in horses with colic. Therefore, the objective was to assess the evolution of HRV parameters and cortisol concentrations in horses with colic. The 43 horses included in this study were categorized into three groups according to the treatment (1, surgical; 2, conservative; 3, euthanized). The HRV and laboratory variables were measured at admission (T1), the day after admission (T2), and at discharge (T3) and compared between groups and over time with an ANOVA with Bonferroni correction. Relationships between the HRV parameters themselves and the laboratory variables was assessed by Pearson correlation coefficients. Evolution of the heart rate (HR) over time, mean normal to normal R intervals (meanNN) and cortisol concentrations indicate a decreased sympathetic stimulation over time in group 1 and 2, in contrast to group 3. For group 3, the meanNN and HR differed significantly to group 2 at T1 and to group 1 and 2 at T2. Treatment induced a change in the HRV and cortisol response in horses managed conservatively or surgically but not in horses that required euthanasia. However, further studies are required to assess the validity of HRV analyses in horses with colic.
心率变异性（HRV）是一种检测自主神经系统变化的非侵入性技术。在患绞痛的马匹中，对其研究甚少。因此，本研究的目的是评估患绞痛马匹的HRV参数和皮质醇浓度的变化情况。本研究纳入的43匹马根据治疗方式分为三组（1.手术治疗；2.保守治疗；3.实施安乐死）。在入院时（T1）、入院后第二天（T2）和出院时（T3）测量HRV和实验室指标，并通过带有Bonferroni校正的方差分析在组间以及随时间进行比较。通过Pearson相关系数评估HRV参数自身与实验室指标之间的关系。与第3组相比，第1组和第2组的心率（HR）、平均正常RR间期（meanNN）和皮质醇浓度随时间推移显示交感神经刺激减少。对于第3组，meanNN和HR在T1时与第2组有显著差异，在T2时与第1组和第2组有显著差异。治疗使接受保守治疗或手术治疗的马匹的HRV和皮质醇反应发生了变化，但对需要实施安乐死的马匹没有影响。然而，需要进一步研究来评估HRV分析在患绞痛马匹中的有效性。
