Paediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Vaccine. 2012 Aug 24;30(39):5785-90. doi: 10.1016/j.vaccine.2012.05.057. Epub 2012 Jun 5.
Although varicella has usually an uncomplicated course in early childhood, several neurological complications may occur. We conducted a study to review the type and the rate of varicella neurological complications in a case series of hospitalized immunologically healthy children over nearly a 8 year period. We also systematically reviewed data from the literature to estimate the rate of varicella neurological complications. In our case reports, the proportion of neurological complications among all those hospitalized for varicella was of 21.7% (CI 17.9-26%). The pooled prevalence of neurological complications resulting from the systematic review of the literature identifies the likelihood of such complications in the range of 13.9-20.4%. Although neurological complications of chickenpox do not frequently result in permanent sequelae, they represent significant determinants of prolonged hospital stay and of other indirect costs. The obtained results may be useful for estimating costs associated with hospitalization from varicella in cost-benefit analysis for immunization.
虽然水痘在幼儿期通常病程不复杂，但也可能出现几种神经系统并发症。我们进行了一项研究，回顾了近 8 年来住院的免疫功能正常的儿童中水痘的神经并发症的类型和发生率。我们还系统地回顾了文献中的数据，以估算水痘神经并发症的发生率。在我们的病例报告中，所有因水痘住院的儿童中，神经系统并发症的比例为 21.7%（95%CI 17.9-26%）。通过对文献的系统回顾，神经系统并发症的总患病率确定了此类并发症的可能性范围在 13.9-20.4%之间。虽然水痘的神经系统并发症并不经常导致永久性后遗症，但它们是延长住院时间和其他间接费用的重要决定因素。所得结果可能有助于在免疫接种的成本效益分析中估算与水痘住院相关的费用。
