Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Department of Neurology, Medical University of Vienna, Vienna, Austria.
Front Immunol. 2021 Oct 19;12:769653. doi: 10.3389/fimmu.2021.769653. eCollection 2021.
To determine whether there is a correlation between myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases and varicella zoster virus (VZV) infection. We provide a case report and performed a study to determine the frequency of MOG antibodies (MOG-IgG) in neurological VZV infections. Patients admitted to the Medical University of Innsbruck from 2008-2020 with a diagnosis of a neurological manifestation of VZV infection (n=59) were included in this study; patients with neuroborreliosis (n=34) served as control group. MOG-IgG was detected using live cell-based assays. In addition, we performed a literature review focusing on MOG and aquaporin-4 (AQP4) antibodies and their association with VZV infection. Our case presented with VZV-associated longitudinally extensive transverse myelitis and had MOG-IgG at a titer of 1:1280. In the study, we did not detect MOG-IgG in any other patient neither in the VZV group (including 15 with VZV encephalitis/myelitis) nor in the neuroborreliosis group. In the review of the literature, 3 cases with MOG-IgG and additional 9 cases with AQP4 IgG associated disorders in association with a VZV infection were identified. MOG-IgG are rarely detected in patients with VZV infections associated with neurological diseases.
为了确定髓鞘少突胶质细胞糖蛋白 (MOG) 抗体相关疾病与水痘带状疱疹病毒 (VZV) 感染之间是否存在相关性。我们提供了一份病例报告，并进行了一项研究，以确定神经 VZV 感染中 MOG 抗体 (MOG-IgG) 的频率。本研究纳入了 2008 年至 2020 年期间因 VZV 感染的神经表现而入住因斯布鲁克医科大学的患者（n=59）；神经伯氏疏螺旋体病患者（n=34）作为对照组。使用活细胞检测法检测 MOG-IgG。此外，我们还进行了一项文献综述，重点关注 MOG 和水通道蛋白-4 (AQP4) 抗体及其与 VZV 感染的关联。我们的病例表现为 VZV 相关性纵向广泛横贯性脊髓炎，MOG-IgG 滴度为 1:1280。在研究中，我们在 VZV 组（包括 15 例 VZV 脑炎/脊髓炎）和神经伯氏疏螺旋体病组均未检测到任何其他患者的 MOG-IgG。在文献综述中，发现了 3 例 MOG-IgG 和另外 9 例与 VZV 感染相关的 AQP4 IgG 相关疾病。在与神经 VZV 感染相关的患者中，很少检测到 MOG-IgG。
