镍催化的未活化卤代烷与酸酐的还原偶联生成酮。
Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides.
机构信息
Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China.
出版信息
Chem Commun (Camb). 2012 Jul 18;48(56):7034-6. doi: 10.1039/c2cc33232a. Epub 2012 Jun 11.
PMID:22684052
Abstract
Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc(2)O and MgCl(2).
摘要
成功开发了使用锌作为末端还原剂，通过温和还原偶联各种未活化的烷基溴化物和碘化物与特别芳基酸酐，来实现镍催化酮形成的方法。这些条件也允许在 Boc(2)O 和 MgCl(2)的存在下，直接偶联烷基碘化物与芳基酸。
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