Pediatric Allergy/Immunology Division, Massachusetts General Hospital for Children, Boston, MA, USA.
J Pediatr Gastroenterol Nutr. 2012 Dec;55(6):641-7. doi: 10.1097/MPG.0b013e3182617a9d.
Breast-feeding provides protection against infections and contains numerous factors that modulate and promote the development of the infant immune system. These factors include secretory IgA, antimicrobial proteins like CD14, cytokines, and fatty acids. Studies examining the role of breast-feeding in the development of allergic disease in infants demonstrate potentially protective as well as neutral or nonprotective effects, likely due to the heterogeneity in their study design. In this overview, we explore the potential role of immune factors in the breast milk, as well as selected probiotics, in the development of allergy.
母乳喂养提供了抗感染保护，并含有许多调节和促进婴儿免疫系统发育的因素。这些因素包括分泌型免疫球蛋白 A、CD14 等抗菌蛋白、细胞因子和脂肪酸。研究母乳喂养在婴儿过敏疾病发展中的作用的结果表明，母乳喂养具有潜在的保护作用，也有中性或非保护作用，这可能是由于其研究设计的异质性。在这篇综述中，我们探讨了母乳中免疫因素以及某些益生菌在过敏发展中的潜在作用。
