基因组学筛选转移基因。
Genomics screens for metastasis genes.
机构信息
University of Washington Medical Center, 1959 N. E. Pacific Street, Seattle, WA 98195, USA.
出版信息
Cancer Metastasis Rev. 2012 Dec;31(3-4):419-28. doi: 10.1007/s10555-012-9362-z.
Abstract
Metastasis is responsible for most cancer mortality. The process of metastasis is complex, requiring the coordinated expression and fine regulation of many genes in multiple pathways in both the tumor and host tissues. Identification and characterization of the genetic programs that regulate metastasis is critical to understanding the metastatic process and discovering molecular targets for the prevention and treatment of metastasis. Genomic approaches and functional genomic analyses can systemically discover metastasis genes. In this review, we summarize the genetic tools and methods that have been used to identify and characterize the genes that play critical roles in metastasis.
摘要
转移是大多数癌症死亡的原因。转移的过程很复杂，需要肿瘤和宿主组织中多个途径的许多基因的协调表达和精细调节。鉴定和描述调节转移的遗传程序对于理解转移过程和发现预防和治疗转移的分子靶点至关重要。基因组方法和功能基因组分析可以系统地发现转移基因。在这篇综述中，我们总结了用于鉴定和描述在转移中起关键作用的基因的遗传工具和方法。
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