miR-23a 是结直肠癌“迁移”和转移的关键调控因子。
miR-23a, a critical regulator of "migR"ation and metastasis in colorectal cancer.
机构信息
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Cancer Discov. 2012 Jun;2(6):489-91. doi: 10.1158/2159-8290.CD-12-0177.
Abstract
Jahid and colleagues have shown that miR-23a promotes the transition from indolent to invasive colorectal cancer through inhibition of the MTSS1 tumor suppressor. This study reveals a novel role of miR-23a in the acceleration of colorectal cancer progression.
摘要
贾希德及其同事表明，miR-23a 通过抑制 MTSS1 肿瘤抑制因子促进从惰性到侵袭性结直肠癌的转变。这项研究揭示了 miR-23a 在加速结直肠癌进展中的新作用。
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本文引用的文献
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miR-23a promotes the transition from indolent to invasive colorectal cancer.miR-23a 促进惰性向侵袭性结直肠癌的转化。
Cancer Discov. 2012 Jun;2(6):540-53. doi: 10.1158/2159-8290.CD-11-0267. Epub 2012 Mar 30.
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[Expression and clinical significance of miR-23a and metastasis suppressor 1 in colon carcinoma].[miR-23a与转移抑制因子1在结肠癌中的表达及临床意义]
Zhonghua Bing Li Xue Za Zhi. 2012 Jan;41(1):28-32.
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