Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA.
Clin Cancer Res. 2011 Dec 1;17(23):7207-9. doi: 10.1158/1078-0432.CCR-11-2440. Epub 2011 Oct 21.
Recent advances in our understanding of the microRNAome (miRNAome) have provided further insights into the molecular pathogenesis of colorectal cancer and shown a potential role for miRNAs in distinguishing molecular subtypes. The mucosa-adenoma-carcinoma model can now integrate miRNAs into the known genetic alterations that drive the progression of colorectal neoplasia.
近年来，我们对 microRNA 组（miRNAome）的理解取得了新的进展，进一步深入了解了结直肠癌的分子发病机制，并显示 miRNA 在区分分子亚型方面具有潜在作用。黏膜-腺瘤-癌模型现在可以将 miRNA 整合到已知的遗传改变中，这些改变推动了结直肠肿瘤的进展。
