Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Virol Sin. 2012 Jun;27(3):165-71. doi: 10.1007/s12250-012-3239-8. Epub 2012 Jun 9.
Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the neutralizing antibody response in the plasma from LTNP and TP against clade B and clade C pseudoviruses. No difference in the neutralizing activities between the plasma from LTNP and TP was found, which was consistent with the most recent reports. In addition, no correlations between the titer or breadth and CD(4+) or viral load in HIV-1 infected individuals were found. The protective roles played by neutralizing antibodies in controlling disease progression of HIV-1 infected people need to be considered in a new viewpoint.
中和抗体被认为是 HIV-1 疫苗评估中一个重要的保护参数。然而，中和抗体在控制 HIV-1 感染者疾病进展中的确切作用仍未确定。在本文中，我们比较了 LTNP 和 TP 血浆中的中和抗体反应对 B 群和 C 群假病毒的保护作用。LTNP 和 TP 血浆中的中和活性没有差异，这与最近的报道一致。此外，在 HIV-1 感染者中，中和抗体的滴度或广度与 CD（4）+或病毒载量之间没有相关性。需要从新的角度考虑中和抗体在控制 HIV-1 感染者疾病进展中的保护作用。
