甘露糖基转移酶基因 migA 和 wapR 以不同的方式调节铜绿假单胞菌产生的核心寡糖糖型的数量。
Rhamnosyltransferase genes migA and wapR are regulated in a differential manner to modulate the quantities of core oligosaccharide glycoforms produced by Pseudomonas aeruginosa.
机构信息
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
出版信息
J Bacteriol. 2012 Aug;194(16):4295-300. doi: 10.1128/JB.05741-11. Epub 2012 Jun 8.
Abstract
migA and wapR are rhamnosyltransferase genes involved in the biosynthesis of Pseudomonas aeruginosa lipopolysaccharide core oligosaccharide. Here, we show that preferential expression of migA and wapR correlated with the levels of uncapped and O polysaccharide-capped core, respectively. wapR is negatively regulated, while migA is positively regulated by RhlR/RhlI quorum sensing.
摘要
migA 和 wapR 是参与铜绿假单胞菌脂多糖核心寡糖生物合成的鼠李糖基转移酶基因。在这里，我们表明 migA 和 wapR 的优先表达分别与无帽和 O 多糖帽核心的水平相关。wapR 受负调控，而 migA 受群体感应 RhlR/RhlI 的正调控。
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