Graduate Program in Cell and Molecular Biology, Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
J Exp Bot. 2012 Jul;63(12):4343-8. doi: 10.1093/jxb/ers157. Epub 2012 Jun 8.
Proper flowering time is vital for reproductive fitness in flowering plants. In Arabidopsis, vernalization is mediated primarily through the repression of a MADS box transcription factor, FLOWERING LOCUS C (FLC). The induction of a plant homeodomain-containing protein, VERNALIZATION INSENSITIVE 3 (VIN3), by vernalizing cold is required for proper repression of FLC. One of a myriad of changes that occurs after VIN3 is induced is the establishment of FLC chromatin at a mitotically repressed state due to the enrichment of repressive histone modifications. VIN3 induction by cold is the earliest known event during the vernalization response and includes changes in histone modifications at its chromatin. Here, the current understanding of the vernalization-mediated chromatin changes in Arabidopsis is discussed, with a focus on the roles of shared chromatin-modifying machineries in regulating VIN3 and FLC gene family expression during the course of vernalization.
适当的开花时间对开花植物的生殖适应性至关重要。在拟南芥中，春化主要通过抑制 MADS 框转录因子 FLOWERING LOCUS C (FLC) 来介导。春化冷诱导的植物同源域蛋白 VERNALIZATION INSENSITIVE 3 (VIN3) 的诱导是 FLC 适当抑制所必需的。VIN3 诱导后发生的无数变化之一是由于富含抑制性组蛋白修饰，使 FLC 染色质处于有丝分裂抑制状态。VIN3 诱导的冷是春化反应中最早已知的事件，包括其染色质组蛋白修饰的变化。在这里，讨论了拟南芥中春化介导的染色质变化的现有认识，重点介绍了在春化过程中共享染色质修饰机制在调节 VIN3 和 FLC 基因家族表达中的作用。
