Liu Yi, Sun Jidong, Wu Cong, Cao Xudong, He Min, You Chao
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Genet Test Mol Biomarkers. 2012 Jul;16(7):822-6. doi: 10.1089/gtmb.2012.0004. Epub 2012 Jun 11.
Interleukin-6 (IL-6) is an important proinflammatory cytokine that plays an important role in the pathogenesis of intracranial aneurysms (IAs). The aim of this study was to investigate the association between the IL-6-572G/C polymorphism and the risk of IAs in a Chinese population. The IL-6-572G/C gene polymorphisms in 220 IA cases and 220 controls were analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. The IL-6-572GG (odds ratio [OR]=3.35, 95% confidence intervals [CIs]=1.65, 6.82; p=0.001) and G allele frequencies (OR=1.48, 95% CIs=1.09, 2.00; p=0.01) in the IA group were higher than those in the control group. The C allele frequencies (OR=0.68, 95% CIs=0.50, 0.92; p=0.01) were significantly lower in patients than in controls. When stratified by the site, shape, size, and the Fisher Grade of IAs, no statistically significant result was observed. This study suggested that the IL-6-572GG genotype was associated with a higher risk of IA in a Chinese population.
白细胞介素-6（IL-6）是一种重要的促炎细胞因子，在颅内动脉瘤（IA）的发病机制中起重要作用。本研究旨在探讨中国人群中IL-6 - 572G/C基因多态性与IA发病风险之间的关联。采用聚合酶链反应-限制性片段长度多态性方法分析了220例IA患者和220例对照者的IL-6 - 572G/C基因多态性。IA组中IL-6 - 572GG（优势比[OR]=3.35，95%置信区间[CIs]=1.65，6.82；p=0.001）和G等位基因频率（OR=1.48，95% CIs=1.09，2.00；p=0.01）高于对照组。患者的C等位基因频率（OR=0.68，95% CIs=0.50，0.92；p=0.01）显著低于对照组。按IA的部位、形状、大小和Fisher分级进行分层时，未观察到统计学上的显著结果。本研究表明，在中国人群中，IL-6 - 572GG基因型与IA的较高发病风险相关。
