Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612, USA.
Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Transl Stroke Res. 2023 Oct;14(5):631-639. doi: 10.1007/s12975-022-01079-4. Epub 2022 Aug 31.
Intracranial aneurysm (IA) rupture is a common cause of subarachnoid hemorrhage (SAH) with high mortality and morbidity. Inflammatory interleukins (IL), such as IL-6, play an important role in the occurrence and rupture of IA causing SAH. With this review we aim to elucidate the specific role of IL-6 in aneurysm formation and rupture in preclinical and clinical studies. IL-6 is a novel cytokine in that it has pro-inflammatory and anti-inflammatory signaling pathways. In preclinical and clinical studies of IA formation, elevated and reduced levels of IL-6 are reported. Poor post-rupture prognosis and increased rupture risk, however, are associated with higher levels of IL-6. By better understanding the relationships between IL-6 and IA formation and rupture, IL-6 may serve as a biomarker in high-risk populations. Furthermore, by better understanding the IL-6 signaling mechanisms in IA formation and rupture, IL-6 may optimize surveillance and treatment strategies. This review examines the association between IL-6 and IA, while also suggesting future research directions.
颅内动脉瘤（IA）破裂是蛛网膜下腔出血（SAH）的常见原因，具有高死亡率和发病率。炎性白细胞介素（IL），如 IL-6，在 IA 的发生和破裂导致 SAH 中起重要作用。通过本综述，我们旨在阐明 IL-6 在临床前和临床研究中在动脉瘤形成和破裂中的具体作用。IL-6 是一种新型细胞因子，具有促炎和抗炎信号通路。在 IA 形成的临床前和临床研究中，报告了 IL-6 水平升高和降低。然而，与较高水平的 IL-6 相关的是较差的破裂后预后和增加的破裂风险。通过更好地了解 IL-6 与 IA 形成和破裂之间的关系，IL-6 可能成为高危人群的生物标志物。此外，通过更好地了解 IL-6 在 IA 形成和破裂中的信号机制，IL-6 可能优化监测和治疗策略。本综述检查了 IL-6 与 IA 之间的关联，同时还提出了未来的研究方向。
