遗传和环境因素对抑郁性人格障碍和 DSM-IV 人格障碍共病的影响。
Genetic and environmental contributions to the co-occurrence of depressive personality disorder and DSM-IV personality disorders.
机构信息
Department of Mental Health, Norwegian Institute of Public Health, Norway.
出版信息
J Pers Disord. 2012 Jun;26(3):435-51. doi: 10.1521/pedi.2012.26.3.435.
One of the main controversies with regard to depressive personality disorder (DPD) concerns the co-occurrence with the established DSM-IV personality disorders (PDs). The main aim of this study was to examine to what extent DPD and the DSM-IV PDs share genetic and environmental risk factors, using multivariate twin modeling. The DSM-IV Structured Interview for Personality was applied to 2,794 young adult twins. Paranoid PD from Cluster A, borderline PD from Cluster B, and all three PDs from Cluster C were independently and significantly associated with DPD in multiple regression analysis. The genetic correlations between DPD and the other PDs were strong (.53-.83), while the environmental correlations were moderate (.36-.40). Close to 50% of the total variance in DPD was disorder specific. However, only 5% was due to disorder-specific genetic factors, indicating that a substantial part of the genetic vulnerability to DPD also increases the vulnerability to other PDs.
关于抑郁性人格障碍（DPD）的主要争议之一涉及与既定的 DSM-IV 人格障碍（PD）的同时发生。本研究的主要目的是使用多变量双胞胎模型来研究 DPD 和 DSM-IV PD 在多大程度上共享遗传和环境风险因素。DSM-IV 人格结构访谈应用于 2794 名年轻成年双胞胎。在多元回归分析中，从 A 群分离出的偏执型 PD、从 B 群分离出的边缘型 PD 以及从 C 群分离出的所有三种 PD 均与 DPD 独立且显著相关。DPD 与其他 PD 之间的遗传相关性很强（.53-.83），而环境相关性则适中（.36-.40）。DPD 的总方差中接近 50%是特定于障碍的。然而，只有 5%是由于特定于障碍的遗传因素造成的，这表明对 DPD 的遗传易感性的很大一部分也增加了对其他 PD 的易感性。
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