Department of Urology, St.-Josefs-Hospital Dortmund-Hörde, Dortmund, Germany.
J Toxicol Environ Health A. 2012;75(8-10):557-65. doi: 10.1080/15287394.2012.675308.
In the 1990s, an uncommonly high percentage of glutathione S-transferase M1 (GSTM1) negative bladder cancer cases (70%) was reported in the greater Dortmund area. The question arose as to whether this uncommonly high percentage of GSTM1 negative bladder cancer cases was due to environmental and/or occupational exposure decades ago. Thus, 15 years later, another study on bladder cancer was performed in the same area after the coal, iron, and steel industries had finally closed in the 1990s. In total 196 bladder cancer patients from the St.-Josefs-Hospital Dortmund-Hörde and 235 controls with benign urological diseases were assessed by questionnaire and genotyped for GSTM1, glutathione S-transferase T1 (GSTT1), and the N-acetyltransferase 2 (NAT2) tag SNP rs1495741. The frequency of the GSTM1 negative genotype was 52% in bladder cancer cases and thus lower compared to a previous study performed from 1992 to 1995 in the same area (70%). NAT2 genotypes were distributed equally among cases and controls (63% slow acetylators). Fewer GSTT1 negative genotypes were present in cases (17%) than in controls (20%).
20 世纪 90 年代，在多特蒙德地区报告了一种罕见的高比例谷胱甘肽 S-转移酶 M1（GSTM1）阴性膀胱癌病例（70%）。人们开始怀疑，这种罕见的高比例 GSTM1 阴性膀胱癌病例是否是由于几十年前的环境和/或职业暴露造成的。因此，15 年后，在煤炭、钢铁和钢铁行业最终于 20 世纪 90 年代关闭后，在同一地区进行了另一项膀胱癌研究。共有 196 名来自多特蒙德-霍尔德圣约瑟夫医院的膀胱癌患者和 235 名良性泌尿科疾病对照者通过问卷调查进行评估，并对 GSTM1、谷胱甘肽 S-转移酶 T1（GSTT1）和 N-乙酰基转移酶 2（NAT2）标记 SNP rs1495741 进行了基因分型。膀胱癌病例中 GSTM1 阴性基因型的频率为 52%，低于同一地区 1992 年至 1995 年进行的先前研究（70%）。NAT2 基因型在病例和对照组中分布均匀（63%为慢乙酰化酶）。病例中 GSTT1 阴性基因型的比例（17%）低于对照组（20%）。
