Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Ave., Edmonton, Alberta, Canada.
FEBS J. 2012 Aug;279(15):2624-31. doi: 10.1111/j.1742-4658.2012.08659.x. Epub 2012 Jul 3.
The act of increasing mass, either in non-dividing cells or in dividing cells seeking to provide new material for daughter cells, depends upon the continued presence of extracellular nutrients in order to conserve mass. For amino acid nutrients, it appears that their insufficiency for new protein synthesis is actively monitored by both prokaryotic and eukaryotic cells, eliciting appropriate cellular responses that may depend not only on bulk nutrient supply, but also on the abundance of specific amino acids.
为了维持质量，无论是在非分裂细胞中还是在试图为子细胞提供新物质的分裂细胞中，增加质量的行为都依赖于细胞外营养物质的持续存在。对于氨基酸营养物质，原核细胞和真核细胞似乎都在积极监测其用于新蛋白质合成的不足情况，并引发适当的细胞反应，这些反应可能不仅取决于大量营养物质的供应，还取决于特定氨基酸的丰度。
