Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai, China.
Can J Physiol Pharmacol. 2012 Jul;90(7):941-5. doi: 10.1139/y2012-080. Epub 2012 Jun 12.
To assess the effect of the drug combination of Schisandra sphenanthera extract (SchE) and Rapamycin (RAPA), 18 healthy subjects were given oral treatments of RAPA alone and with SchE. Pharmacokinetic investigations and indexes of hepatic and renal functions, as well as other indices of oral RAPA administration (2 mg), were performed both before and after the SchE treatment period. Whole-blood RAPA concentrations were determined by enzyme-linked immunosorbent assay. The research found that the mean whole-blood RAPA AUC(0-∞), C(max), and t(max) increased almost 2-, 2.1-, and 1.3-fold, respectively, and CL/F (-38.0%) decreased almost 1.6-fold in these subjects when RAPA was administered with SchE compared with oral RAPA administered alone. The results of this study proved that SchE can increase the oral bioavailability of RAPA and will add important information to the interaction area between drugs and herbal products.
为了评估五味子提取物（SchE）和雷帕霉素（RAPA）联合用药的效果，给 18 名健康受试者分别口服 RAPA 和 RAPA 联合 SchE 进行治疗。在 SchE 治疗期前后，进行药代动力学研究以及肝肾功能和其他口服 RAPA 给药指标（2 mg）的检测。采用酶联免疫吸附法检测全血 RAPA 浓度。研究发现，与单独口服 RAPA 相比，当 RAPA 与 SchE 联合给药时，受试者的全血 RAPA AUC(0-∞)、C(max)和 t(max)分别增加约 2 倍、2.1 倍和 1.3 倍，CL/F（-38.0%）减少约 1.6 倍。该研究结果证明，SchE 可增加 RAPA 的口服生物利用度，并将为药物与草药产品相互作用领域增添重要信息。
