Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Cancer Chemother Pharmacol. 2023 Feb;91(2):103-119. doi: 10.1007/s00280-023-04504-z. Epub 2023 Jan 27.
Natural products, also referred to as dietary supplements, complementary and alternative medicines, and health or food supplements are widely used by people living with cancer. These products are predominantly self-selected and taken concurrently with cancer treatments with the intention of improving quality of life, immune function and reducing cancer symptoms and treatment side effects. Concerns have been raised that concurrent use may lead to interactions resulting in adverse effects and unintended treatment outcomes. This review provides an overview of the mechanisms by which these interactions can occur and the current evidence about specific clinically important natural product-drug interactions. Clinical studies investigating pharmacokinetic interactions provide evidence that negative treatment outcomes may occur when Hypericum perforatum, Grapefruit, Schisandra sphenanthera, Curcuma longa or Hydrastis canadensis are taken concurrently with common cancer treatments. Conversely, pharmacodynamic interactions between Hangeshashinto (TJ-14) and some cancer treatments have been shown to reduce the side effects of diarrhoea and oral mucositis. In summary, research in this area is limited and requires further investigation.
天然产物，也被称为膳食补充剂、补充和替代药物以及健康或食品补充剂，被癌症患者广泛使用。这些产品主要是自我选择的，并与癌症治疗同时使用，目的是提高生活质量、免疫功能，减轻癌症症状和治疗副作用。人们担心同时使用可能会导致相互作用，从而产生不良反应和意想不到的治疗结果。本综述概述了这些相互作用发生的机制以及关于特定临床重要的天然产物-药物相互作用的现有证据。研究药代动力学相互作用的临床研究提供了证据表明，贯叶金丝桃、葡萄柚、五味子、姜黄或升麻与常见癌症治疗同时使用时，可能会导致治疗结果不佳。相反，汉方制剂（TJ-14）与某些癌症治疗之间的药效学相互作用已被证明可以减轻腹泻和口腔粘膜炎的副作用。总之，该领域的研究有限，需要进一步调查。
