糖皮质激素对小鼠乳腺肿瘤病毒基因表达的调控

Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones.

作者信息

Varmus H E, Ringold G, Yamamoto K R

出版信息

Monogr Endocrinol. 1979;12:253-78. doi: 10.1007/978-3-642-81265-1_14.

Abstract

Several laboratories have documented that glucocorticoid hormones markedly stimulate the expression of mouse mammary tumor virus genes in a variety of mouse mammary tumor cells and in infected heterologous cells. The effect of the hormone appears to be a rapid and specific augmentation of the synthesis of viral RNA, mediated by interaction with glucocorticoid receptor proteins. The availability of virus-specific reagents and recent developments in the molecular biology of RNA tumor viruses now permit a highly refined analysis of hormonal regulation in this experimental system.

摘要

几个实验室已证明，糖皮质激素能显著刺激多种小鼠乳腺肿瘤细胞及受感染的异源细胞中鼠乳腺肿瘤病毒基因的表达。激素的作用似乎是通过与糖皮质激素受体蛋白相互作用，快速且特异性地增强病毒RNA的合成。病毒特异性试剂的可得性以及RNA肿瘤病毒分子生物学的最新进展，使得在这个实验系统中对激素调节进行高度精细的分析成为可能。