Knepper J E, Medina D, Butel J S
J Virol. 1986 Aug;59(2):518-21. doi: 10.1128/JVI.59.2.518-521.1986.
Expression of endogenous mouse mammary tumor virus sequences varied over the course of development of the mammary gland during primary pregnancy and lactation in virus-free BALB/c mice. Although RNA from all regions of the genome was detected, both the level and temporal regulation of expression were different for long terminal repeat-, env-, and gag-pol-specific RNAs. Analysis of the methylation status of proviral DNA indicated differential accessibility of the three endogenous units during development. The results demonstrated noncoordinate regulation of mouse mammary tumor virus expression with respect to provirus template utilized and specific transcripts accumulated.
在无病毒的BALB/c小鼠初次妊娠和哺乳期间，内源性小鼠乳腺肿瘤病毒序列的表达在乳腺发育过程中有所变化。尽管检测到了来自基因组所有区域的RNA，但长末端重复序列、env和gag-pol特异性RNA的表达水平和时间调控是不同的。对前病毒DNA甲基化状态的分析表明，在发育过程中这三个内源性单元的可及性存在差异。结果表明，小鼠乳腺肿瘤病毒的表达在利用的前病毒模板和积累的特定转录本方面存在非协同调控。
