Sanotskaia N V, Mikhaĭlov V P, Matsievskiĭ D D
Biull Eksp Biol Med. 1990 Sep;110(9):254-7.
In experiments on white rats, guinea pigs and cats it was shown that intravenous infusion of phospholipase A2 (FLA2) caused the development of pulmonary edema (PE) in guinea pigs, but did not cause it in rats and cats. Bilateral vagotomy on the neck led to the appearance of the expressed edemogenous effect of FLA2 on the lungs. Pentobarbital anesthesia decreased the effect of vagotomy. This effect is not connected with the turn off of the efferent impulsation in vagus nerves as the infusion of atropine did not repeat the influence of vagotomy. Authors assume that the action of FLA2 is realized across the secretion of humoral factor in vagotomized animals and the increase of the permeability of the aero-hematic barrier.
在对白鼠、豚鼠和猫进行的实验中发现，静脉注射磷脂酶A2（FLA2）可导致豚鼠发生肺水肿（PE），但对大鼠和猫则无此作用。颈部双侧迷走神经切断术会导致FLA2对肺部产生明显的致水肿效应。戊巴比妥麻醉可降低迷走神经切断术的效果。这种效应与迷走神经传出冲动的阻断无关，因为注射阿托品并未重现迷走神经切断术的影响。作者认为，FLA2的作用是通过迷走神经切断动物体内体液因子的分泌以及气血屏障通透性的增加来实现的。
