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乳腺导管内移植：研究癌前病变进展的工具。

Intra-mammary ductal transplantation: a tool to study premalignant progression.

机构信息

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

出版信息

J Mammary Gland Biol Neoplasia. 2012 Jun;17(2):131-3. doi: 10.1007/s10911-012-9259-z. Epub 2012 Jun 12.

DOI:10.1007/s10911-012-9259-z
PMID:22688217
Abstract

Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer. Although there is extensive information on the cellular and molecular changes in DCIS, there is limited ability to functionally test. The critical changes in premalignant progression. This review summarizes our experience with a recently developed method which provides. The opportunity to functionally test the molecular events occuring to functionally test the molecular events occurring in the initial changes in premaligant progression; i.e., the step from non-invasive to invasive behavior.

摘要

导管原位癌（DCIS）是非浸润性乳腺癌的强制性前体。尽管有关于 DCIS 中细胞和分子变化的广泛信息，但功能测试的能力有限。在癌前进展中关键的变化。这篇综述总结了我们最近开发的一种方法的经验，该方法提供了。在癌前进展的初始变化中发生的分子事件进行功能测试的机会；即从非浸润性到浸润性行为的步骤。

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Intra-mammary ductal transplantation: a tool to study premalignant progression.乳腺导管内移植：研究癌前病变进展的工具。
J Mammary Gland Biol Neoplasia. 2012 Jun;17(2):131-3. doi: 10.1007/s10911-012-9259-z. Epub 2012 Jun 12.
2
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Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model.人原发性导管原位癌（DCIS）亚型特异性病理学在小鼠管内（MIND）异种移植模型中得以保留。
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Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion.体内导管原位癌进展模型的表达谱分析确定B细胞淋巴瘤-9是乳腺癌侵袭的分子驱动因素。
Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z.
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TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells.TNFAIP3 对于 FGFR1 激活促进的癌前 DCIS.COM 人乳腺上皮细胞的增殖和致瘤作用是必需的。
Breast Cancer Res. 2018 Aug 15;20(1):97. doi: 10.1186/s13058-018-1024-9.
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Atypical ductal hyperplasia and ductal carcinoma in situ of the breast associated with perineural invasion.非典型导管增生及乳腺导管原位癌伴神经周围浸润。
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[Establishing a cytogenetic and morphological progression models of invasive breast cancer. Comparative genomic hybridization (CGH) in malignant and premalignant tumors of the female breast].[建立浸润性乳腺癌的细胞遗传学和形态学进展模型。女性乳腺恶性和癌前肿瘤的比较基因组杂交（CGH）]
Pathologe. 2000 Sep;21(5):375-82. doi: 10.1007/s002920000404.
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本文引用的文献

1
Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer.调控导管原位癌进展为浸润性乳腺癌的差异表达基因。
Cancer Res. 2012 Sep 1;72(17):4574-86. doi: 10.1158/0008-5472.CAN-12-0636. Epub 2012 Jul 2.
2
Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia.导管原位癌进展为浸润性乳腺癌与 EMT 和肌上皮基因表达程序有关。
Breast Cancer Res Treat. 2012 Jun;133(3):1009-24. doi: 10.1007/s10549-011-1894-3. Epub 2011 Dec 2.
3
Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model.
Myoepithelial cell differentiation markers in ductal carcinoma in situ progression.
导管原位癌进展中的肌上皮细胞分化标志物
Am J Pathol. 2015 Nov;185(11):3076-89. doi: 10.1016/j.ajpath.2015.07.004. Epub 2015 Sep 4.
4
Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure.具有三维器官样结构的原位导管癌微流控模型
BMC Cancer. 2015 Jan 21;15:12. doi: 10.1186/s12885-015-1007-5.
5
Critical questions in mammary gland development, lactational biology and breast cancer.乳腺发育、泌乳生物学和乳腺癌中的关键问题。
J Mammary Gland Biol Neoplasia. 2012 Jun;17(2):89-90. doi: 10.1007/s10911-012-9260-6.
人原发性导管原位癌（DCIS）亚型特异性病理学在小鼠管内（MIND）异种移植模型中得以保留。
J Pathol. 2011 Dec;225(4):565-73. doi: 10.1002/path.2969. Epub 2011 Sep 26.
4
An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ.一种人源肿瘤异种移植于小鼠乳腺导管内的模型可模拟原位导管癌的亚型。
Breast Cancer Res. 2009;11(5):R66. doi: 10.1186/bcr2358.
5
Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.MCF10DCIS.com异种移植瘤进展过程中的动态基质-上皮相互作用
Int J Cancer. 2007 May 15;120(10):2127-34. doi: 10.1002/ijc.22572.
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Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.利用禽逆转录病毒载体将癌基因导入体内的乳腺，可在小鼠模型中引发并促进癌症发生。
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17396-401. doi: 10.1073/pnas.0608607103. Epub 2006 Nov 7.
7
Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.将增生性肺泡结节移植到雌性C3H小鼠无腺体的乳腺脂肪垫中后乳腺肿瘤的发生情况。
Cancer Res. 1959 Jun;19(5):515-20.